The Eastern Carpathians region is characterized by its peripherical position within the frame of superior geopolitical formations, the component of which it was. This feature typical for this area in the course of its historical development was the consequence of traditional economical backwardness of the region. On the other hand this position resulted in overlap of different cultural and confessional systems. Exactly in this region there have been formed religious and cultural borders between Western and Eastern Europe appearing not only in confessional and ethnical differences, but also in diversity of life style, as well as material and religious culture. This fact is proved by the gradual decrease of typical signs of the West-Christian culture and increase of the East-Christian culture in the direction from west to east. The main bearer of peculiarities and individual features of the region, in spite of Slovak dominancy, from the aspect of nationality became Ruthens and Ukrainians and from the aspect of religion Greek Catholic and Orthodox Churches. They present the identity of the Eastern Carpathians region in Slovak context. This identity raised in the process of interference of religious and cultural diversity of the region. One of the effects of this interference is the relatively high degree of tolerance of people living here.