We investigated the effect of industrial emission application on 12 ewes in experimental conditions. The emission from a copper plant was applied in an amount of 2.65 g per head and day on a genetic apparatus, body weight and selected biochemical indicators. The first ewe perished of copper intoxication symptoms on the 65th day and the last one on the 84th day. The body weight of experimental animals was evidently lower at the end of the experiment in comparison with the control ones (P < 0.05). The loss in weight made 7.25 kg in the course of experiment for an experimental sheep. The Cu concentration in the blood serum found at the animals of the experimental group between the 50th and 77th day was significantly higher (P < 0.01) than at the control group. An increased activity of enzymes effected by feeding of emissions was observed in AST already from the 50th day. The AST values were higher at the experimental ewes statistically (P < 0.01) on the 50th, 70th and 77th day when compared with the control group and also the GGT on the 70th and 77th day (P < 0.01). The difference of C.bil. content in the blood serum at the end of experiment was between the experimental and control group on the level of significance, P < 0.01. We verified the mutagenic effect of tested industrial emission at experimental ewes on the 14th and 42nd day of experiment by a significant increase of SCE-s (P. < 0.01). The number of chromosomal aberrations at the tested experimental animals before the start of the experiment and on the 42nd day was not evidently different (0.024 +/- 0.0149, or 0.04 +/- 0.01.26).