The monitoring will be based on the evaluation of the health status of the population and from the exposure to noxious factors in the environment. Biological materials in selected localities of Slovakia will be measured to determine pollutant levels. The monitoring of health damage will be based on studying the following indicators: acute respiration diseases and their complications in the juvenile population (i. e. children up to 15 years of age), abnormally increased mortality of heart and respiration diseases in endangered population groups, epidemics of food-transmitted infectious diseases, and human burdening by xenobiotics from the food chain. Organic contaminants (pesticide residues, PCBs) as well as inorganic (toxic elements, nitrates) will be analysed in biological materials (blood, urine, liver, kidneys, adipose tissue), in mother´s milk and in diet samples. The monitoring will be carried out in 3 basic regions differentiated according to the degree of environmental contamination. The degree of environmental contamination will be based on current available information. Children and young people up to the age of 15, and men and women of three age cathegories will be clinically examined. More than seven thousand people are expected to be examined in total. On the basis of the obtained data, numerous measures are taken for the minimalization of adverse effects of a polluted environment on public health.