The quality of human life is a result of interactive interrelations of environmental, medicinal, social and economic conditions, conserning human and social development. Environmental aspects of the life quality have not been or marginaly only been evaluated in economic and psychological analyses. However natural environment, where people are living, is important determinant of the life quality. Due to it represents objective / real conditions of well-faire on one-side and subjective feeling of “good” life on other side.  The concept of ecosystem services is used for identification and analyses of ecological determinants of the human life quality in rural areas. Natural ecosystems, ecosystem processes and biodiversity (which determines ecosystem functioning) will be used as environmental indicators of the life quality. Biodiversity loss and ecosystem degradation due to increasing economic and other human activities, cause decreasing of the ecosystem ability to satisfy the society needs and following decreasing of the life quality. One way how to change regional differences is to change of approaches to ecosystems, by diversification of the ecosystem use on the basis of the concept of multifunctional management. These new approaches need education of new environmental managers in the field of integrated use of natural resources/ecosystem services on the principles of ecosystem management.