The contribution presents the conclusions of the prognosis of development of science and research in settlement and regional development in Slovakia up to 2015. The prognosis is prepared by the methodology of Technology Foresight. It explains the state of settlement-regional development of the Slovak Republic, as well as the input of science and research into this development. It describes the competence of science, especially of basic research, to react to actual problems in this field from personnel, infrastructural and institutional viewpoints. It elucidates the new trends of settlement-regional development and social-spatial needs of information society. In this context, research priorities are proposed that correspond with the new developmental trends, as well as the needs to solve the problems of settlements and regions in Slovakia.